In step1 (select samples for analysis), click on sample grouping name 'Histone'. This will show 2 options namely H3k4me3 and H3K27me3. We want to analyze the 2 histones separately. Choose H3K4me3 first by checking radio button 'include'. This step will filter samples in the analysis. In this case it will include only one type of selected histone. In step2, select ``cell'' as sample grouping for further analysis. Then choose clustering on ``Genes'' and press ``Analyze''. Figure depicts the snapshot of this step.