Laboratory for Computational Systems Biology






Mario, Medvedovic Maureen Sartor
Research Associate, PhD Candidate
318 Kettering

Personal Web Site

Research Description

Maureen Sartor has recently published a new statistical method for testing for differentially expressed genes in microarrays using a hierarchical empirical Bayesian model. Her current work is focused on further methods for analyzing microarray data, specifically more powerful tests for discovery key biological pathways affected in microarray experiments and additional tests for differential expression using splines within hierarchical Bayesian models.


Xavier University, Cincinnati, OH B.S. 1998 Math with minors in Computer Science and Biology
North Carolina State Univ., Raleigh, NC M.BMA 2000 Biomathematics
University of Cincinnati, Cincinnati, OH  Biostatistics (Expected PhD by Dec. 2007)

Professional Experience

2002- present, Bioinformatics Research Associate, Department of Environmental Health, University of Cincinnati
2002 Member of the Center for Environmental Genetics, University of Cincinnati
2001- 2002 Statistical Analyst, Medpace Inc., Cincinnati, OH
2000 Statistician, contractor for Toxicogenomics division, GlaxoSmithKline, Research Triangle Park, NC



  • Sartor MA, Tomlinson CR, Wesselkamper SC, Sivaganesan S, Leikauf GD, and Medvedovic M. Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in microarray experiments. BMC Bioinformatics 7: 538, 2006. (Support Page)

  • Sartor MA, Zorn AM, Schwanekamp J, Halbleib D, Karyala S, Howell ML, Dean GE, Medvedovic M, Tomlinson CR. A new method to remove hybridization bias for interspecies comparison of global gene expression profiles uncovers an association between mRNA sequence divergence and differential gene expression in Xenopus. Nucleic Acids Research 34(1):185-200. 2006.

  • Schwanekamp JA, Sartor MA, Karyala S, Halbleib D, Medvedovic M, Tomlinson CR. Genome-wide analyses show that nuclear and cytoplasmic RNA levels are differentially affected by dioxin. Biochim Biophys Acta. 1759(8-9): 388-402, 2006.

  • Erwin CR, Jarboe MD, Sartor MA, Medvedovic M, Warner BW, Bates MD. Developmental Characteristics of Adapting Small Intestine Crypt Cells. Gastroenterology 130(4):1324-32. 2006.

  • Mesa CJr., Mirza M, Mitsutake N, Sartor MA, Medvedovic M, Tomlinson CR, Knauf JA, Weber G, Fagin JA. Conditional activation of the RET/PTC3 and B-RAFV600E oncoproteins in thyroid cells is associated with unique patterns of gene expression that predict distinct functional properties and a preferential role of BRAF in extracellular matrix remodeling. Cancer Research, 66(13):6521-9. 2006.

  • Deng M, Chen WL, Takatori A, Peng Z, Zhang L, Mongan M, Parthasarathy R, Sartor M, Miller M, Yang J, Su B, Kao WW, Xia Y. A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing. Mol Biol Cell. 17(8): 3446-55, 2006.

  • Wesselkamper SC, McDowell SA, Medvedovic M, Dalton TP, Deshmukh HS, Sartor MA, Case LM, Henning LN, Borchers MT, Tomlinson CR, Prows DR, Leikauf GD. The Role of Metallothionein in the Pathogenesis of Acute Lung Injury. Am J Respir Cell Mol Biol. 34(1):73-82. 2006.


  • Puxeddu E, Knauf JA, Sartor MA, Mitsutake N, Smith EP, Medvedovic M, Tomlinson CR, Moretti S, Fagin JA. RET/PTC-induced gene expression in thyroid PCCL3 cells reveals early activation of genes involved in regulation of the immune response Endocr Relat Cancer. 12(2):319-34. 2005

  • Kann S., Huang M., Estes C., Reichard J.F., Sartor M.A., Xia Y., Puga A.: Arsenite-induced aryl hydrocarbon receptor nuclear translocation results in additive induction of phase I and synergistic induction of phase II genes. Mol. Pharm. 68:336-346, 2005

  • Kann S., Estes C., Reichard R.F., Huang M.-Y., Sartor M.A., Schwemberger S., Chen Y., Dalton T.P., Shertzer H.G., Xia Y., Puga A. Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status. Toxicol Sci 87:365-384, 2005.

  • Wesselkamper SC, Case LM, Henning LN, Borchers MT, Tichelaar JW, Mason JM, Dragin N, Medvedovic M, Sartor MA, Tomlinson CR, Leikauf GD. Gene Expression Changes During the Development of Acute Lung Injury: Role of TGF-{beta}. Am J Respir Cell Mol Biol. 172(11):1399-411. 2005


  • Bahassi, E.M., Karyla, S., Tomlinson, C.R., Sartor, M.A., Medvedovic, M., Hennigan, R.F. Inhibition of AP-1 Function Differentially Affects Tumor Cell Proliferation and Migration. Clinical and Experimental Metastasis, (In Press) 2004.

  • Puga, A., Sartor, M.A., Huang, M-Y, Kerzee, K.J., Wei, Y-D, Tomlinson, C.R., Baxter, C.S., Medvedovic, M. Gene expression profiles of mouse aourta and cultured vascular smooth muscle cells are widely different, yet show common responses to dioxin exposure. Cardiovascular Toxicology 4(4):385-404.2004.  (Abstract)

  • Leikauf GD, Hardie WD, Wesselkamper SC, Bachurski CJ, Medvedovic M, Sartor MA, Tomlinson CR, McDowell SA, Henning LM, Case LM, Tichelaar JW, Prows DR, Korfhagen TR: Resolving Gene-Environment Interactions in Complex Traits: Acute Lung Injury. Am J Respir Cell Mol Biol. (In Press)

  • Whitsett JA, Bachurski CJ, Barnes KC, Bunn PA, Jr., Case LM, Cook DN, Crooks D, Duncan MW, Dwyer-Nield L, Elston RC, Fessler MB, Franklin WA, Friedman N, Garcia JG, Geraci MW, Glasgow C, Glasser SW, Hardie WD, Henning LM, Johnson GL, Kawkitinarong K, Keith RL, Korfhagen TR, Leikauf GD, Liggett SB, Malcolm KC, Malkinson AM, Mariani TJ, McDowell SA, McGraw DW, Medvedovic M, Moss J, Nogee LM, Nonas S, Pacheco-Rodriguez G, Palmer LJ, Peters DG, Prows DR, Redline S, Regev A, Sartor MA, Schwartz DA, Silverman EK, Steagall WK, Stearman RS, Taveira-DaSilva A, Tichelaar JW, Tomlinson CR, Tsukada K, Weaver TE, Wert SE, Wesselkamper SC, Worthen GS, Xu Y, Zerbe L, Zhang Y, Zhang Y, Choi AM, and Kaminski N, Functional genomics of lung disease. Am.J.Respir.Cell Mol.Biol. 31: S1-S81, 2004.

  • Zhang J., Moseley A., Jegga A.G., Gupta A., Witte D.P., Sartor M., Medvedovic M., Williams S.S., Ley-Ebert C., Coolen L., Egnaczyk G., Genter M.B., Lehman M., Lingrel J., Maggio J., Parysek L., Walsh R., Xu M., Aronow B.J. Neural system-enriched gene expression, relationship to biological pathways and neurological diseases. Physiologic Genomics 18: 167-183, 2004.

  • Sartor, M.A., Schwanekamp, J., Halbleib, D., Mohamed, I., Karyala, S., Medvedovic, M. and Tomlinson, C.R. Microarray results improve significantly as hybridization approaches equilibrium. Biotechniques 36: 790-796, 2004.(Abstract)

  • Karyala, S., Guo, J., Sartor, M., Medvedovic, M., Kann, S., Puga, A., Ryan, P., and Tomlinson, C.R.. Different global gene expression profiles in benzo[a]pyrene- and dioxin-treated vascular smooth muscle cells of AHR-knockout and wild-type mice. Cardiovascular Toxicology, 4: 47-74. 2004.(Abstract)

  • Guo, J., Sartor, M., Karyala, S., Medvedovic, M., Puga, A., Ryan, P., Tomlinson, C.R. Expression of genes in the TGF-β signaling pathway is significantly deregulated in smooth muscle cells from aorta of aryl hydrocarbon receptor knockout mice. Toxicology and Applied Pharmacology 194: 79-89. 2004.(Abstract)

2003 and before

  • Morgan KT, Ni H, Brown HR, Yoon L, Qualls CW, Crosby LM, Reynolds R, Gaskill B, Anderson SP, Kepler TB, Brainard T, Liv N, Easton M, Merrill C, Creech D, Sprenger D, Conner G, Johnson Pr, Fox T, Sartor M, Richard E, Kuruvilla S, Casey W, Benavides G. Application of cDNA microarray technology to in vitro toxicology and the selection of genes for a RT-PCR-based screen for oxidative stress in Hep-G2 cells.  Toxicol Pathol. 30(4):435-51, 2002.

  • Hester SD, Benavides GB, Sartor M, Yoon L, Wolf DC, Morgan KT.  Normal gene expression in male F344 rat nasal transitional and respiratory epithelium.  Gene. 285(1-2):301-10, 2002.