Research Description |
Maureen Sartor has recently
published a new statistical method for testing for differentially
expressed genes in microarrays using a hierarchical empirical Bayesian
model. Her current work is focused on further methods for analyzing microarray
data, specifically more powerful tests for discovery key biological pathways
affected in microarray experiments and additional tests for differential
expression using splines within hierarchical Bayesian models. |
|
Education |
Xavier University,
Cincinnati, OH B.S. 1998 Math with minors in Computer Science and
Biology North Carolina State Univ., Raleigh, NC M.BMA 2000
Biomathematics University of Cincinnati, Cincinnati, OH Biostatistics
(Expected PhD by Dec. 2007) |
Professional
Experience
|
2002- present,
Bioinformatics Research Associate, Department of Environmental Health,
University of Cincinnati 2002 Member of the Center for
Environmental Genetics, University of Cincinnati 2001- 2002
Statistical Analyst, Medpace Inc., Cincinnati, OH 2000
Statistician, contractor for Toxicogenomics division, GlaxoSmithKline,
Research Triangle Park, NC
|
|
Publications
|
2006
-
Sartor MA, Tomlinson CR, Wesselkamper SC, Sivaganesan S, Leikauf GD,
and Medvedovic M. Intensity-based hierarchical Bayes method improves
testing for differentially expressed genes in microarray experiments.
BMC
Bioinformatics
7: 538, 2006.
(Support Page)
-
Sartor MA, Zorn AM, Schwanekamp J, Halbleib D, Karyala S, Howell ML,
Dean GE, Medvedovic M, Tomlinson CR. A new method to remove
hybridization bias for interspecies comparison of global gene
expression profiles uncovers an association between mRNA sequence
divergence and differential gene expression in Xenopus.
Nucleic Acids Research 34(1):185-200. 2006.
-
Schwanekamp
JA, Sartor MA, Karyala S, Halbleib D, Medvedovic M, Tomlinson
CR. Genome-wide analyses show that nuclear and cytoplasmic RNA levels
are differentially affected by dioxin. Biochim
Biophys Acta.
1759(8-9): 388-402, 2006.
-
Erwin CR, Jarboe MD, Sartor MA, Medvedovic M, Warner BW, Bates
MD. Developmental Characteristics of Adapting Small Intestine Crypt
Cells.
Gastroenterology 130(4):1324-32. 2006.
-
Mesa CJr., Mirza M, Mitsutake N, Sartor MA, Medvedovic M,
Tomlinson CR, Knauf JA, Weber G, Fagin JA. Conditional activation of
the RET/PTC3 and B-RAFV600E oncoproteins in thyroid cells is
associated with unique patterns of gene expression that predict
distinct functional properties and a preferential role of BRAF in
extracellular matrix remodeling.
Cancer Research, 66(13):6521-9. 2006.
-
Deng
M, Chen WL, Takatori A, Peng Z, Zhang L, Mongan M, Parthasarathy R, Sartor M,
Miller M, Yang J, Su B, Kao WW, Xia Y. A role for the mitogen-activated protein
kinase kinase kinase 1 in epithelial wound healing. Mol Biol
Cell. 17(8):
3446-55, 2006.
-
Wesselkamper SC, McDowell SA, Medvedovic M, Dalton TP, Deshmukh HS,
Sartor MA, Case LM, Henning LN, Borchers MT, Tomlinson CR, Prows DR,
Leikauf GD. The Role of Metallothionein in the Pathogenesis of Acute
Lung Injury.
Am J Respir Cell Mol Biol. 34(1):73-82. 2006.
2005
-
Puxeddu E, Knauf JA, Sartor MA, Mitsutake N, Smith EP, Medvedovic M,
Tomlinson CR, Moretti S, Fagin JA. RET/PTC-induced gene expression in
thyroid PCCL3 cells reveals early activation of genes involved in
regulation of the immune response Endocr Relat Cancer.
12(2):319-34. 2005
-
Kann S., Huang M., Estes C., Reichard J.F., Sartor M.A.,
Xia Y., Puga A.: Arsenite-induced aryl hydrocarbon receptor nuclear
translocation results in additive induction of phase I and synergistic induction
of phase II genes. Mol. Pharm. 68:336-346,
2005.
-
Kann S., Estes C., Reichard R.F., Huang M.-Y., Sartor M.A.,
Schwemberger S., Chen Y., Dalton T.P., Shertzer H.G., Xia Y., Puga A.
Butylhydroquinone protects cells genetically deficient in glutathione
biosynthesis from arsenite-induced apoptosis without significantly changing
their prooxidant status. Toxicol Sci 87:365-384,
2005.
-
Wesselkamper SC, Case LM, Henning LN, Borchers MT, Tichelaar JW, Mason
JM, Dragin N, Medvedovic M, Sartor MA, Tomlinson CR, Leikauf GD. Gene
Expression Changes During the Development of Acute Lung Injury: Role
of TGF-{beta}. Am J Respir Cell Mol Biol. 172(11):1399-411.
2005
2004
-
Bahassi, E.M., Karyla, S.,
Tomlinson, C.R., Sartor, M.A., Medvedovic, M., Hennigan, R.F.
Inhibition of AP-1 Function Differentially Affects Tumor Cell
Proliferation and Migration. Clinical and Experimental Metastasis,
(In Press) 2004.
-
Puga, A., Sartor, M.A., Huang, M-Y,
Kerzee, K.J., Wei, Y-D, Tomlinson, C.R., Baxter, C.S., Medvedovic, M.
Gene expression profiles of mouse aourta and cultured vascular smooth
muscle cells are widely different, yet show common responses to dioxin
exposure. Cardiovascular Toxicology
4(4):385-404.2004. (Abstract)
-
Leikauf GD, Hardie WD, Wesselkamper
SC, Bachurski CJ, Medvedovic M, Sartor MA, Tomlinson CR, McDowell
SA, Henning LM, Case LM, Tichelaar JW, Prows DR, Korfhagen TR: Resolving
Gene-Environment Interactions in Complex Traits: Acute Lung Injury.
Am J Respir Cell Mol Biol. (In Press)
-
Whitsett JA, Bachurski CJ, Barnes
KC, Bunn PA, Jr., Case LM, Cook DN, Crooks D, Duncan MW, Dwyer-Nield L,
Elston RC, Fessler MB, Franklin WA, Friedman N, Garcia JG, Geraci MW,
Glasgow C, Glasser SW, Hardie WD, Henning LM, Johnson GL, Kawkitinarong
K, Keith RL, Korfhagen TR, Leikauf GD, Liggett SB, Malcolm KC, Malkinson
AM, Mariani TJ, McDowell SA, McGraw DW, Medvedovic M, Moss J,
Nogee LM, Nonas S, Pacheco-Rodriguez G, Palmer LJ, Peters DG, Prows DR,
Redline S, Regev A, Sartor MA, Schwartz DA, Silverman EK, Steagall WK,
Stearman RS, Taveira-DaSilva A, Tichelaar JW, Tomlinson CR, Tsukada K,
Weaver TE, Wert SE, Wesselkamper SC, Worthen GS, Xu Y, Zerbe L, Zhang Y,
Zhang Y, Choi AM, and Kaminski N, Functional genomics of lung disease.
Am.J.Respir.Cell Mol.Biol. 31: S1-S81, 2004.
-
Zhang J., Moseley A., Jegga A.G.,
Gupta A., Witte D.P., Sartor M., Medvedovic M., Williams S.S.,
Ley-Ebert C., Coolen L., Egnaczyk G., Genter M.B., Lehman M., Lingrel
J., Maggio J., Parysek L., Walsh R., Xu M., Aronow B.J. Neural
system-enriched gene expression, relationship to biological pathways and
neurological diseases. Physiologic Genomics 18: 167-183, 2004.
-
Sartor, M.A., Schwanekamp, J.,
Halbleib, D., Mohamed, I., Karyala, S., Medvedovic, M. and
Tomlinson, C.R. Microarray results improve significantly as
hybridization approaches equilibrium. Biotechniques 36: 790-796,
2004.(Abstract)
-
Karyala, S., Guo, J., Sartor, M.,
Medvedovic, M., Kann, S., Puga, A., Ryan, P., and Tomlinson, C.R..
Different global gene expression profiles in
benzo[a]pyrene- and dioxin-treated vascular smooth muscle
cells of AHR-knockout and wild-type mice. Cardiovascular Toxicology,
4: 47-74. 2004.(Abstract)
-
Guo, J., Sartor, M.,
Karyala, S., Medvedovic, M., Puga, A., Ryan, P., Tomlinson, C.R.
Expression of genes in the TGF-β signaling pathway is significantly
deregulated in smooth muscle cells from aorta of aryl hydrocarbon
receptor knockout mice. Toxicology and Applied Pharmacology 194:
79-89. 2004.(Abstract)
2003 and before
-
Morgan KT, Ni H, Brown HR, Yoon L,
Qualls CW, Crosby LM, Reynolds R, Gaskill B, Anderson SP, Kepler TB, Brainard
T, Liv N, Easton M, Merrill C, Creech D, Sprenger D, Conner G, Johnson Pr, Fox
T, Sartor M, Richard E, Kuruvilla S, Casey W, Benavides G. Application of cDNA
microarray technology
to in vitro toxicology and the selection of genes for a
RT-PCR-based screen
for oxidative stress in Hep-G2 cells. Toxicol Pathol.
30(4):435-51, 2002.
-
Hester SD, Benavides GB, Sartor
M, Yoon L, Wolf DC, Morgan KT. Normal gene expression in male F344 rat nasal transitional and respiratory epithelium.
Gene. 285(1-2):301-10, 2002.
|
|
|